Web1 Mar 2003 · Expressed at highest levels in testis, stomach, skeletal muscle, lung, kidney, pancreas, small intestine and colon. It is also detected in normal ovarian surface epithelial … WebThis gene encodes an extracellular heparan sulfate endosulfatase. The encoded enzyme selectively removes 6-O-sulfate gro ups from heparan sulfate chains of heparan sulfate …
Single cell type - SULF1 - The Human Protein Atlas
The first signs of Sulf1 dysregulation were found in ovarian cancer. The expression of Sulf1 mRNA was found to be downregulated or absent in a majority of ovarian cancer specimens. [18] The same investigators also found lowered mRNA expression in breast, pancreatic, and hepatic malignant cell lines. [18] See more Sulfatase 1, also known as SULF1, is an enzyme which in humans is encoded by the SULF1 gene. Heparan sulfate proteoglycans (HSPGs) act as co-receptors for numerous heparin-binding growth … See more Heparan sulfate proteoglycans (HSPGs) are widely expressed throughout most tissues of nearly all multicellular species. The function of HSPGs extends beyond providing an extracellular matrix (ECM) structure and scaffold for cells. They are integral regulators … See more HS enzymatic specificity of QSulf1 was first analyzed. QSulf1 enzymatic specificity on 6-O sulfates was linked to the trisulfated disaccharides (HexA,2SGlcNS,6S) … See more In addition to cancer, Sulf1 and Sulf2 were studied with respect to normal development including neural, muscle, vasculogenesis and skeletal development. Recently, much of what is known was from studies on Sulf1/2 knockout mice. Skeletal Development See more Before the cloning and characterization of Sulf1 and Sulf2, HS composition was thought to be unchanging after localization to the … See more Sulf1 and Sulf2 are new members of a superfamily of arylsulfatases, being closely related to arylsulfatase A, B (ARSA; ARSB) and glucosamine 6-sulfatase (G6S). The x-ray crystal structure … See more The next section gives a detailed description of Sulf1 and Sulf2’s involvement in cancer. Much of what is known about signaling pathways mediated by Sulfs has been … See more WebRabbit polyclonal Sulfatase 1/SULF1 antibody. Validated in IHC and tested in Human. Cited in 8 publication(s). ... skeletal muscle, lung, kidney, pancreas, small intestine and colon. It is also detected in normal ovarian surface epithelial cells. Down-regulation seen in ovarian carcinoma cell lines, ovarian cancers, breast, pancreatic, renal ... famous in small town
Extracellular heparan 6-O-endosulfatases SULF1 and SULF2 in …
Web1 May 2024 · Lots of studies had demonstrated that SULF1 was associated with platinum resistance. Down-regulation of SULF1 in ovarian cancer cells led to an attenuation of … WebThis study aims to develop a machine learning model incorporating genomic data such as Single-Nucleotide Polymorphisms (SNPs) of Human Sulfatase 1 (SULF1) with a CT … Web15 May 2024 · To decipher SULF1’s role in the reactive bone stroma, we created a bone marrow biomimetic hydrogel incorporating perlecan, PCa cells, macrophages, and fibroblastic bone marrow stromal cells. ... , with the majority showing reduced levels of SULF1 in progressive ovarian, hepatocellular, breast, and head and neck carcinomas ... famous in singapore